Ruxolitinib for myelofibrosis
نویسنده
چکیده
Myelofibrosis (MF), a myeloproliferative neoplasm, is a disease associated with a significant burden of symptoms, shortened survival and an array of standard treatment regimens which have historically lacked impact and efficacy. The discovery in 2005 of the highly prevalent JAK2V617F-activating tyrosine kinase mutation, strongly associated with myeloproliferative neoplasms, led to the rapid development of a new class of drugs, JAK inhibitors, for the treatment of MF. These drugs have produced a profound effect upon splenomegaly, proliferative blood counts and constitutional symptoms, which are characteristic of MF, and have given hope to both patients and physicians who treat this debilitating disease. This article reviews the current evidence for the use of the JAK inhibitor ruxolitinib, which has completed Phase III trials and with which there is the most extensive clinical experience, as well as assessing other JAK inhibitors in clinical development.
منابع مشابه
Effect of ruxolitinib therapy on myelofibrosis-related symptoms and other patient-reported outcomes in COMFORT-I: a randomized, double-blind, placebo-controlled trial.
PURPOSE To assess the effects of ruxolitinib on symptom burden and quality of life (QoL) and to evaluate the ability of the modified Myelofibrosis Symptom Assessment Form (MFSAF) v2.0 to measure meaningful changes in myelofibrosis-related symptoms in patients with myelofibrosis. PATIENTS AND METHODS COMFORT-I (Controlled Myelofibrosis Study With Oral JAK Inhibitor Treatment-I) is a double-bli...
متن کاملCase-report: EBV driven lymphoproliferative disorder associated with Ruxolitinib
BACKGROUND Ruxolitinib, a novel inhibitor of Janus kinases 1 and 2, was recently approved for the treatment of myelofibrosis but, recently, attention has been drawn to potential side effects and especially opportunistic infections and virus reactivations. EBV reactivation has not previously been reported to occur in association with Ruxolitinib. CASE PRESENTATION We report a case of a 57 year...
متن کاملEfficacy, safety, and survival with ruxolitinib in patients with myelofibrosis: results of a median 3-year follow-up of COMFORT-I.
In the phase III COMFORT-I study, the Janus kinase 1 (JAK1)/JAK2 inhibitor ruxolitinib provided significant improvements in splenomegaly, key symptoms, and quality-of-life measures and was associated with an overall survival benefit relative to placebo in patients with intermediate-2 or high-risk myelofibrosis. This planned analysis assessed the long-term efficacy and safety of ruxolitinib at a...
متن کاملA myelofibrosis case that develops mycobacterial infection after ruxolitinib treatment
Ruxolitinib is a novel therapeutic agent which is being used in the treatment of myelofibrosis. In the literature, there are reports of opportunistic infections along with tuberculosis during ruxolitinib treatment. Herein, we aimed to report a post-polycythemic myelofibrosis case that developed mycobacterial infection after ruxolitinib treatment. 64 years old man was diagnosed as polycythemia v...
متن کاملThree-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis.
Ruxolitinib is a potent Janus kinase (JAK)1/JAK2 inhibitor that has demonstrated rapid reductions in splenomegaly and marked improvement in disease-related symptoms and quality of life in patients with myelofibrosis (MF). The present analysis reports the 3-year follow-up (median, 151 weeks) of the efficacy and safety of Controlled Myelofibrosis Study With Oral Janus-associated Kinase (JAK) Inhi...
متن کامل